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Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke
《医学前沿(英文)》 doi: 10.1007/s11684-023-1041-7
关键词: SARS-CoV-2 ischemic stroke stroke hemorrhagic stroke cerebral venous thrombosis vaccination
Piezoelectric pump with flexible venous valves for active cell transmission
《机械工程前沿(英文)》 2022年 第17卷 第4期 doi: 10.1007/s11465-022-0712-4
关键词: venous valve flexible venous valve cell transmission organ-on-a-chip system piezoelectric device
Classification and treatment of orbital venous malformations: an updated review
Tianyuan Li, Renbing Jia, Xianqun Fan
《医学前沿(英文)》 2019年 第13卷 第5期 页码 547-555 doi: 10.1007/s11684-018-0623-2
关键词: orbit venous malformation treatment sclerotherapy laser embolization
Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination
《医学前沿(英文)》 2021年 第15卷 第6期 页码 938-941 doi: 10.1007/s11684-021-0895-9
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 86-93 doi: 10.1007/s11684-011-0118-x
Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.
关键词: adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 319-323 doi: 10.1007/s11684-017-0553-4
Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). Here, we report a Chinese 22-year-old young man who developed recurrent and serious VTE in cerebral veins, visceral veins, and deep veins of the lower extremity. Laboratory tests and direct sequencing of and were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant c.572_574delAGA in . This combination of the two mutations was absent in 400 healthy subjects each from southern and northern China. Then, we summarized all the mutations of the and gene reported in the Chinese Han population. This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity can result in severe VTE and that the coexistence of different genetic factors may increase the risk of VTE.
关键词: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
《医学前沿(英文)》 2023年 第17卷 第3期 页码 518-526 doi: 10.1007/s11684-022-0958-6
关键词: acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 22-34 doi: 10.1007/s11684-012-0178-6
Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes—as for all other diseases—a “mass approach” aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention.
关键词: stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs carotid endarterectomy
HUA Rong, SUN Yongwei, WU Zhiyong
《医学前沿(英文)》 2008年 第2卷 第3期 页码 244-247 doi: 10.1007/s11684-008-0046-6
Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 472-485 doi: 10.1007/s11684-021-0832-y
关键词: neuronal progenitor cells resveratrol cerebral ischemia neuronal differentiation mitochondrial metabolism positron emission tomography
Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via
Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu
《医学前沿(英文)》 2019年 第13卷 第6期 页码 680-689 doi: 10.1007/s11684-018-0673-5
关键词: anti-
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 29-35 doi: 10.1007/s11684-010-0012-y
关键词: risk factor stroke prothrombin plasminogen activator inhibitor type-1 polymorphism thrombophilia biomarker
Implications of astrocytes in neurovascular coupling
You ZHOU MD, Chang-Kai SUN MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 43-45 doi: 10.1007/s11684-010-0019-4
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.
关键词: arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells
标题 作者 时间 类型 操作
Classification and treatment of orbital venous malformations: an updated review
Tianyuan Li, Renbing Jia, Xianqun Fan
期刊论文
Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral
null
期刊论文
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
期刊论文
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese
期刊论文
Effects of combined procedure and devascularization alone on hyperdynamics of the portal venous system
HUA Rong, SUN Yongwei, WU Zhiyong
期刊论文
survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral
Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang
期刊论文
Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via
Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu
期刊论文
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
期刊论文
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
null
期刊论文